A new theme park, built on the original site of Jurassic Park, creates a genetically modified hybrid dinosaur, the Indominus Rex, which escapes containment and goes on a killing spree.

Four years after the destruction of Isla Nublar, Biosyn operatives attempt to track down Maisie Lockwood, while Dr Ellie Sattler investigates a genetically engineered swarm of giant insects.