A dying CIA agent trying to reconnect with his estranged daughter is offered an experimental drug that could save his life in exchange for one last assignment.

On the run in the year 1987, Bumblebee finds refuge in a junkyard in a small California beach town. On the cusp of turning 18 and trying to find her place in the world, Charlie Watson discovers Bumblebee, battle-scarred and broken.

Miles Morales catapults across the Multiverse, where he encounters a team of Spider-People charged with protecting its very existence. When the heroes clash on how to handle a new threat, Miles must redefine what it means to be a hero.

Teen Miles Morales becomes the Spider-Man of his universe and must join with five spider-powered individuals from other dimensions to stop a threat for all realities.